Posts Tagged ‘Research’

Useful site for medical literature

December 28, 2007

A (medical) student’s guide to medical literature site: designed especially for medical students but can be used by anyone who wants a guide to the medical literature. Quite useful to those of us wanting to understand for ourselves what science reveals about birth insofar as it has been studied by the medical industry, or community.

“If you are having trouble researching a medical question, or want an easy guide to critical appraisal of journal articles, this is the site for you!”

Some of the features of this site are:

Calendar: New Media, Cyberstudies, more

November 9, 2007

Notes on upcoming events for my calendar: (All emphases, mine)

Session “Lives On-Line: New work in critical cyberstudies” on Friday, Nov. 16, (5pm – 6:15pm)

“Internet-Based Research: Past, Present and Future” National Communication Association convention, Chicago, Saturday, Nov. 17, (9:30am-10:45am) Palmer House, Salon 7

Dan Hess, Abstract summary:

Title: Internet-Based Research: Past, Present and Future
Abstract: The Internet has had a dramatic impact on the ability to understand the behavior, attitudes and perceptions of consumers. The omnipresent nature of the Web enables research on any level — from global to hyperlocal, from actively self-reported responses to
passive, real time measurement. Whether in marketing, media, academia, politics, government or elsewhere, every research practitioner has been somehow touched by the capabilities that the internet has brought to bear. In this session, Dan Hess will examine
the roots and evolution of research on the Internet, the current state and applications of the industry, and emerging technologies such as those used to analyze social trends and tonality of online community discussions. Hess will also review opportunities for academic and commercial researchers to increase their interaction around Internet research, to the benefit of both parties.

Exploring New Media Worlds: Changing Technologies, Industries, Cultures, and Audiences in Global and Historical Context

An international conference hosted by
Texas A&M University, February 29 to March 2, 2008

Integrating fields of study in a time of change; setting a new agenda for media studies.

Papers and proposals are invited on any aspect of the conference themes, offering reports of new research, position-taking conceptual essays, discussions of media and telecommunication policy, and both international and historical comparisons on changing technologies, industries, cultures, and audiences.

The program will include keynote speakers, roundtable discussions, thematic panels, prominent scholars as respondents, and time for interaction. A wide selection of papers from the conference will be published. Travel grants are available for student members of the National Communication Association (see our webpage for more information).

Keynote speakers:
Lawrence Grossberg; Steve Jones; Vincent Mosco; and Ellen Seiter.

Confirmed participants:
Carole Blair, Sandra Braman, Celeste Condit, Bruce Gronbeck, Andrea Press, Ronald Rice, Paddy Scannell, Arvind Singhal, Joseph Turow, Angharad Valdivia.
Conference on Ethics, Technology and Identity
Delft/The Hague, June 18 – 20, 2008

This conference aims to discuss the theme of ‘ethics and identity’ in ight of new (information) technology. Key-note speakers include: David Velleman, Oscar Gandy, Robin Dillon, David Shoemaker.

For more information: http://www.ethicsandtechnology.eu/ETI.

(One can dream!)

SSRI antidepressants during pregnancy? No!

October 26, 2007

Dr. Peter Breggin clearly spells out the consequences for the babies of pregnant women who take SSRI antidepressants.  He lays out how the FDA and the CDC are not representing the facts accurately. Read the entire post, (Huffington) Pregnant Mothers Should Not Take SSRI Antidepressants.

Here is some of it: (my emphases)

On June 28, 2007 more than 250 headlines around the world promised that SSRI antidepressants (such as Prozac, Paxil, Zoloft, and Celexa) are safe for pregnant mothers and their developing babies. “Mom’s Antidepressant Use Poses Little Danger to Baby,” heralded the Atlanta Journal Constitution. “Antidepressants pose low birth defect risk,” claimed Boston Globe. The New York Times ran with the Associated Press’s article titled “Antidepressants Not Big Risk for Defects.” The Wall Street Journal’s coverage was titled “Reassurance on Antidepressants in Pregnancy.” The day before the news stories broke, the Centers for Disease Control spun the news in advance with a press release headlined, “New Study Finds Few Risks of Birth Defects from Antidepressant Use During Pregnancy” (CDC Division of Media, 2007).

The headlines and the CDC press release were incredibly misleading. In the CDC study, several severe birth defects were doubled or nearly tripled in frequency when SSRIs were taken in the first trimester. This combined with the other known toxic effects of SSRIs, including brain damage and dysfunction, make these drugs contraindicated in pregnancy.

SSRI antidepressant use by pregnant mothers in the first trimester of pregnancy have been shown to have previously unidentified links to three birth defects in two new studies reported in the New England Journal of Medicine. One study was associated with the Centers for Disease Control and Prevention (CDC) (Alwan et al., 2007) and the other with Boston University (Louik et al., 2007).

The study led by Sura Alwan and colleagues involving the CDC showed the following: “Anencephaly–birth without a forebrain–showed a 2.4 times greater occurrence in women who had taken SSRIs in the first trimester.” This is a catastrophic, fatal birth defect that is not correctable.

The study examined histories of 9622 cases of birth defects and 4092 controls who were infants born without birth defects. Some stillbirths (occurring at 20+ weeks gestation) were included but if anencephaly resulted in a spontaneous miscarriage or a planned abortion, these events would not appear in this study’s findings.

Omphalocele–babies born with organs outside the body–was found to be present 2.8 times as often in the SSRI-treated mothers compared to the control group. Some media portrayed this birth defect as a small hernia of the umbilical cord–but severity of the condition varies, usually requires surgery as well as weeks to years of adapting, and can be life-threatening.

Craniosynostosis–the premature closing of one or more sutures or fibrous joints knitting the bones of the infant’s skull–showed 2.5 times more prevalence in infants exposed in utero to SSRIs. This condition also varies in severity. It can be primarily a bone condition of the skull or it can be secondary to an underdeveloped brain in the infant.

Craniosynostosis occurs in about four per 10,000 births according to the National Institutes of Health. A 2.8 times greater occurrence of this condition will cause 2,305 more U.S. babies to be born each year with this birth defect as a result of their mothers taking SSRIs in the first trimester of pregnancy.

In the abstract to the report, the CDC study claimed that it found no association between SSRI use in pregnancy and heart defects in neonates. However, that’s not true. The study found that obese women who did not use SSRIs had an increased risk with heart defects and that obese women who did use SSRIs had an even greater risk of neonatal heart defects with an adjusted odds ratio of 5.9 (95% CI, 2.4-14.3)!

The second study by Carol Louik and her colleagues did not find an overall correlation between SSRI use and the two defects, craniosynostosis and omphalocele. It did however find an association between sertraline (Zoloft) and both omphalocele and septal defects in the heart, and between paroxetine (Paxil) and right ventricular outflow tract obstruction defects of the heart.

Louik made many statements to the press reassuring people, in effect, not to worry. She made no mention of other birth defects and neonatal problems associated with SSRI antidepressants. Her study had funding from two pharmaceutical companies, including GlaxoSmithKline, the manufacturer of Paxil (Seward, 2007), one of the most implicated antidepressants in regard to birth defects. The company’s money was well spent. Thanks in part to Louik’s highly publicized comments, headlines throughout the country played down the risk.

Nor are these the only birth defects related to SSRI consumption during pregnancy. In December of 2005, the FDA issued a Public Health Advisory warning that the risk of congenital malformation, especially of the heart, was increased by the consumption of Paxil in the first trimester of pregnancy. The American College of Obstetricians and Gynecologists (ACOG) (2006) warned pregnant women to avoid taking Paxil and also showed concern about any antidepressant exposure during pregnancy. Yet the CDC and researchers are using the new studies to exonerate SSRIs. This is clearly an orchestrated attempt to reassure the public after the FDA’s and ACOG’s earlier warnings.

The 2007 CDC study offers an illuminating discussion of other study findings concerning abnormal in utero development, including delayed ossification (bone development). “A specific role of serotonin in cardiac and craniofacial morphogenesis in the rodent embryo has also been established,” according to Alwan, et al. (2007) in the CDC study.

Newborns also go through withdrawal when their mothers have taken antidepressants during pregnancy. One study found a rate of 30% in neonates exposed in utero to SSRIs (Levinson-Castiel et al., 2006). Withdrawal symptoms in infants reported in various studies include irritability, high-pitched or weak crying, tremors, poor muscle tone, disturbed sleep, rapid breathing and respiratory distress, and increased admissions to the neonatal intensive care unit.
In addition, children exposed in utero to SSRIs have an increased risk of developing persistent pulmonary hypertension at birth. This disorder, which is estimated to occur in one or two infants for every 1000 live births, will occur six times more frequently in children exposed to SSRIs after the twentieth week of pregnancy. The disorder causes “significant morbidity and mortality” (Food and Drug Administration, 2006). These children have difficulty getting enough oxygen into their lungs. The two recent studies in the New England Journal of Medicine limited themselves to SSRI exposure during the first trimester; but the neonatal pulmonary hypertension studies show that some hazards will develop during exposure later in pregnancy. Again, the CDC and the researchers drew no attention to these hazards.

Withdrawal reactions confirm further potentially disastrous consequences of SSRIs to neonates that the CDC and the researchers failed to consider in their reassuring statements. Withdrawal reactions confirm that the brain of the fetus has been bathed in SSRIs and that is has suffered significant functional changes. It should be no surprise that it is not good to bath the growing brain in toxic drugs like SSRIs. Serotonin is intimately involved in the development of the brain in utero and SSRIs inhibit normal brain cell development (Norrholm and Ouimet, 2000). It is also known that SSRIs cause myriad toxic effects on neurons in living animals, causing brain cells to grow abnormally (Wegerer et al., 1999; Kalia et al., 2000). Unavoidably, similar effects must be taking place in the human fetus exposed to SSRIs. In addition, the SSRIs cause drastic biochemical imbalances in the brain, many of them persistent or permanent. At present we have no way of measuring the harmful impact on the growing brain and the future mind of the fetus; but exposure to SSRIs is bound to be harmful in the long run.

Also alarming is the Wall Street Journal report that antidepressant use during pregnancy has jumped from 5.7% in1999 to 13.4% in 2003 (Seward, 2007). The data was based on Medicaid patients and could be higher for the general population.

The reassuring attitude promoted in the CDC’s press release flew in the face of evidence linking SSRI exposure during pregnancy to increased birth defects, and the additional evidence of SSRI toxicity in the developing brain. It proclaimed that the study “found no significant increase in the risks for the majority of birth defects assessed…” But I’ve never heard of any prescribed drug that increases birth defects “for the majority of birth defects.” The assertion was sheer nonsense, carefully calculated to mislead and obfuscate.

Women and their doctors who only catch the headlines created by these studies are being grossly misled. SSRIs should never be used during pregnancy.

…when the mother has been taking an SSRI antidepressant, increasing her risk by 240%, we must hold responsible the doctor who prescribed it, the drug company who manufactured and falsely promoted it, and the medical establishment that covers up and minimizes the drastic hazards associated with these toxic chemicals, including risks to adults, children and the unborn.

Again, this is a must-read.

Calendar: Media, Communication and Humanity Conference

October 4, 2007

Where I’ll be next September, with a little luck.

Fifth Anniversary Conference: Media, Communication and Humanity

Sunday 21st – Tuesday 23rd September 2008

In celebration of our Department’s fifth anniversary year, we invite critical thinking about how the media and communications environment is implicated in shaping our perceptions of the human condition and thus, increasingly, mediating human values, actions and social relations. We welcome proposals for papers offering theoretical insight and/or empirical work on this theme, focused on the five linked areas below.

Communication and Difference
Democracy, Politics and Journalism Ethics
Globalisation and Comparative Studies
Innovation, Governance and Policy
Media and New Media Literacies

Abstracts should be submitted by 1 March 2008.

See conference website for further details.

Confirmed speakers:

Sandra Ball-Rokeach
Annenberg School for Communication, USA

Lilie Chouliaraki
LSE, UK

Peter Dahlgren
Lund University, Sweden

Daniel Dayan
Centre National de la Recherche Scientifique, France

John Downing
Southern Illinois University, USA

Anthony Giddens
LSE, UK

Carolyn Marvin
Annenberg School for Communication, USA

Mark Poster
University of California, Irvine, USA

Cyberbullying — thinking, part I

October 2, 2007

All of the following comes from  The Targets of Aggression, David P. Barash (Chronicle Website). Please read the entire article.  These are the main parts that are helping to form my thoughts on cyberbullying.

I am very interested in on one of the email lists I participate in, how much there is an encouragement for women who are suffering and in psychic or emotional pain to unleash on others and to payback others, sometimes, who have been felt to have been unsupportive or wronged them. This sometimes goes under the rubric of “not being silent” or compared to the activism of the suffragettes working for the women’s vote. Yes, really. There seems to be a dismissal of the idea that there can be a complexity in approach. That on the list, one must either rail against or one is being submissive, a good little girl. I am interested in the role of such a list dynamic in terms of fueling aggression and healing.

And now Barash:

When an individual suffers pain, he most often responds by passing it on to someone else. When possible, that “someone else” is the perpetrator, the original source of the pain. But if this cannot be achieved, then others are liable to be victimized, regardless of innocence.

Usually the wheels of mayhem are set in motion when someone is wronged, and typically the deeper the wrong, the more bloody the response. It is noteworthy that even here, in works of the imagination (where, one might think, anything goes), only rarely are bad guys presented as doing evil for evil’s sake: the mustache-twirling villain who gleefully ties the heroine to the railroad tracks because he is simply cruel, and that’s that. Almost inevitably, for a bad character to be believable, he or she must be shown to have suffered some injury. Then it all makes sense.

Redirected aggression — the passing of pain from one victim to another — is not merely the stuff of literature and drama. Art reflects our world, and sadly, the urge to pass along pain lurks behind modern warfare no less than it did behind medieval pageantry, leaving its mark in the genocidal wars of the 20th century as well as those that threaten to overwhelm the 21st. It underlies many of the most prominent, enduring themes of literature, history, anthropology, psychology, and religion. It haunts our criminal courts, our streets, our battlefields, our homes, our hearts. There is nothing new about the phenomenon. Much is new, on the other hand, in our ability to understand it.

When animals respond to stress and pain by redirecting their aggression outside themselves, whether biting a stick or, better yet, another individual, it appears that they are protecting themselves from stress. By passing their pain along, such animals minister to their own needs. Although a far cry from being ethically “good,” it is definitely “natural.”

Redirected aggression does not simply derive from irrationality or human nastiness, but — along with retaliation and revenge — is entrenched in the very fabric of the natural world, part of a continuum involving nature’s response to pain. The biology of redirected aggression goes a long way toward explaining not only its apparent senselessness but its universality as well. It shows up across the ages, as we’ve seen, across cultures, and across social units, from individuals to communities to nations.

It feels bad to be a victim, but the pain can often be somewhat assuaged by victimizing someone else in turn.

Recently physiologists have uncovered the hormonal basis for such behavior. Animals and people subjected to attack or threat experience “subordination stress,” as a result of which their adrenal hormones go up, along with blood pressure and the probability of developing ulcers. But — and this is crucial — when given the opportunity to “take it out” on someone else, victims show no sign of stress. By passing along their pain, they modulate their own internal distress while generating trouble for the next ones down the line. Think, the biologist Robert Sapolsky suggests, of the fellow who doesn’t get ulcers but causes them!

As to the evolutionary advantage of such a system, it seems clear that individuals who respond to painful situations by striking out at someone else have been more successful than those who sit back and “take it,” because such individuals are less likely to be victimized the next time around. In social species, including our own, individuals are exquisitely sensitive to a variant of Lenin’s dictum “who, whom?” The cost of being victimized includes a loss of reputation; that is, being seen as exploitable: Who did what to whom, and what happened as a result? Evolution would most likely reward victims who — even if unable to retaliate against the actual perpetrator — conspicuously “take it out” on someone else.

To understand how and why people engage in redirected aggression is to gain insight into seemingly disconnected events. For example, the power and ubiquity of scapegoating are revealed afresh: from Old Testament accounts in which the transgressions and sins of the people were placed upon the head of a goat, which was then slaughtered or driven away, to current psychological theory whereby families often establish a “designated transgressor” who is blamed for any dysfunction. At the societal level, African-Americans have undoubtedly been the foremost recipients of that dubious honor: In a now-classic study, the psychologists Carl Hovland and Robert Sears found that they could predict the number of Southern lynchings occurring during any given year between 1882 and 1930 simply by knowing the price of cotton. When cotton went down, the frequency of lynchings went up. Not that white Southern racists literally blamed African-Americans every time cotton prices declined; rather, a bad economy led to an outpouring of anger, resentment, and frustration, which was then turned against a conspicuous and powerless minority. The economic and social pain of poor whites was passed on to blacks, without any conscious awareness of the scapegoating involved. The situation was clearly cultural, the process all too “natural.”

We might also want to reconsider “justice” and ask what is really going on when victims demand punishment, nearly always claiming, of course, that they are not out for revenge. But, in fact, aren’t they insisting — although not in so many words — that their pain be offloaded onto someone else? Once the wheels of pain have begun to spin, what really seems to matter is that someone — anyone — must suffer, must be made to “pay.” By the same token, consider the fact that crime victims typically resent the presence of exculpatory evidence, which is likely to lead to an acquittal: If their interest were simply in seeing justice done, shouldn’t they applaud any information that makes it less likely that an innocent person might be punished, and thus more likely that the criminal-justice system will instead spend its energy on finding the real culprit? It appears that the accumulated burden of physiology, evolution, and cultural expectation is so great that redirected aggression typically feels better than no response at all. Revealingly, there is a deep insistence on the part of victims and their families that — by virtue of their suffering — they are entitled to a defendant’s punishment, almost without regard to the matter of guilt. Moreover, the urge among victims to redirect their aggression is so strong that society steps in to make sure that this powerful impulse is handled decorously.

Modern science may even owe its existence to scapegoating, or, rather, to those who were able to overcome the urge to redirect their anger and pain. The argument, in brief, is that when bad things have happened to innocent people, there has been a powerful tendency for those people to seek someone, or some group, to blame. And so Jews were slaughtered during the Great Plague, and accused witches were especially likely to be burned whenever times were hard. By taking out their pain on such supposed transgressors, a burden was lifted from the suffering survivors. Today, of course, we know that people get sick because of disease organisms, not the “evil eye.” The point is that in order for science as we now understand it to have developed, it may well have been necessary for people to stop looking for the causes of disasters — and thus of their pain — in scapegoats and to begin searching in the natural world. In short, we didn’t so much stop burning witches because we had developed science, but ra-ther, we developed science only when we were able to get beyond burning witches.

Denying this impulse has been harder than one might think, since it not only invites physiological and evolutionary distress but also opens other vulnerabilities. (“To err is human,” quipped S.J. Perelman, “to forgive, supine.”) Thus it is one thing to espouse compassion and nonviolence, but we live in the real world, which contains threatening, dangerous, and hurtful individuals, requiring that we ask some hard questions. Such as: What should be done about violent transgressors, notably sociopaths and other perpetrators of evil, those with “poisonous personalities” who act upon their venom? If it is not acceptable to pass along our pain, how should we respond? What will provide order, security, and personal satisfaction, as well as minimizing subordination stress, without simply passing along the pain of the victimized? And without creating new victims?

That leads to another difficult question: If people who seek to hurt others are doing so because they have themselves been hurt, does that diminish their responsibility or guilt? Should we pity the poor perpetrator? Are all victimizers themselves previous victims? And what if they are? Does that let them off the hook? When does passing the pain become passing the buck?

Fortunately, there are ways out of the pain-passing trap. Redirected aggression — and to some extent, violence generally — isn’t inevitable, even though, because of our deeper inclinations, forgiveness is difficult. The world’s great ethical systems have long struggled to define an acceptable defense of victims that preserves personal and collective security without falling into excess. That challenge is particularly appropriate at a time when the word “evil” is bandied about by politicians and extremists to condone war and terrorism, no less than wars against terrorism. Hence we might all be well advised to explore not only how pain and aggression are typically misplaced or displaced, but also how they should be placedwhich is to say, the same way that porcupines are reputed to make love: very carefully.

The world’s oldest wisdom traditions have long been concerned with just that. Pain is prominent in Buddhism, which is founded upon the recognition that suffering is ubiquitous and unavoidable, yet can be minimized. The first of Buddhism’s “Four Noble Truths,” that life inevitably entails pain, is followed immediately by specific methods to reduce suffering, called the “the Eightfold Path.” In addition, among the fundamental teachings of Mahayana Buddhism is the kshanti paramita: “the capacity to receive, bear, and transform the pain inflicted on you by your enemies and also by those who love you.”

Christian tradition, too, venerates and validates the role of pain. Christ’s agony is widely taken as crucially related to God’s redemption of humanity. Hidden within dense layers of theology is this equation, one that is, however, rarely made explicit: the more pain (the more suffering on the part of Jesus), the more redemption for the rest of us. But why? Perhaps because the crucifixion of Christ, who is considered the epitome of innocence, provides an especially potent example of scapegoating as a route to social cleansing. Insofar as Christ suffered (“for our sins”), does that suffering enhance the social, personal, and even biochemical status of the rest of us, helping to overcome subordination stress among his followers?

In a masterpiece of painfully accurate revelation, G.K. Chesterton once wrote that Christianity hasn’t been tried and found wanting; rather, it has been found difficult and left untried. Never has that been more true than in cases of personal pain and our reaction to it. Thus, Jesus urged us to love our enemies, and, if slapped, to turn the other cheek. But for millennia — before Jesus and after — hu-man beings and their animal brethren have been far more likely to respond to pain and injury with a retaliating barrage of the same sort, generating yet more injury, more pain.

Perhaps Jesus did not entirely appreciate the magnitude of the demand he was making upon Homo sapiens, because in asking his followers to refrain from retaliation — to absorb pain without passing it on to someone else — he was asking people to inhibit one of their most widely shared, deep-seated inclinations. Nonetheless, potential solutions are all based on an equally deep, equally shared truth: that human beings, perhaps unique among animals, are capable, at least on occasion, and once the issues are made clear, of acting against the promptings of their often troublesome bio-logic.

Birth Stories by Rachel

October 1, 2007

I am far behind on everything. Have been traveling and finishing grant documents that are due. I am preparing a presentation on cyber bullying. Still, trying to gain trace of my records of retired OB and no longer in existence hospital. So, so much to do but all intriguing and energizing. Meanwhile, here are Rachyl’s birth stories. Be sure to read about her MA thesis, Composing Birth.

The birth of Grey Forest Walt

The birthrite of Samuel Rune